| Life Form Name | Origins | Episode or Film First Seen in | Series |
| Acamarians | Acamar 3 | The Vengeance Factor | (TNG) |
| Akritiri | Delta Quad. | The Chute | (VOY) |
| Alcyones | <unknown> | Haven | (TNG) |
| Aldeans | Aldea | When the Bough Breaks | (TNG) |
| Allasomorph | Daled 4 | The Duaphin | (TNG) |
| Anaphasic Life-Form | <unknown> | Sub Rosa | (TNG) |
| Andorians | Andoria | Journey to Babel | (TOS) |
| Angosians | Angosia 3 | The Hunted | (TNG) |
| Antedeans | Antede 3 | Manhunt | (TNG) |
| Anticans | Antica | Lonely Among us | (TNG) |
| Apollo | Earth | Who Mourns for Adonials | (TOS) |
| Arbazan | <unknown> | The Foresaken | (DS9) |
| Argelians | Argelius 2 | Wolf in the Fold | (TOS) |
| Argosian | <unknown> | Dax | (DS9) |
| Argrathi | Argratha | Hard Time | (DS9) |
| Armus | Vagra 2 | Skin of Evil | (TNG) |
| Bajorans | Bajor | Emissary | (DS9) |
| Balduk Warriors | <unknown> | New Ground | (TNG) |
| Bandi | Deneb 4 | Encounter at Farpoint | (TNG) |
| Baneans | Delta Quad. | Ex Post Facto | (VOY) |
| Barkonians | Barkon 4 | Thine Own Self | (TNG) |
| Barolians | <unknown> | Unification | (TNG) |
| Barzans | Barzan | The Price | (TNG) |
| Benzites | Benzar | Coming of Age | (TNG) |
| Berellians | <unknown> | Redemption | (TNG) |
| Beta Renner Cloud | Space | Lonely Among Us | (TNG) |
| Beta 12a Entity | <unknown> | Day of the Dove | (TOS) |
| Betazoids | Betazed | Haven | (TNG) |
| Bolians | Bolarus 9 | Allegiance | (TNG) |
| Boraalans | Boraal 2 | Homeward | (TNG) |
| Borg | Delta Quad. | Q Who | (TNG) |
| Boslics | <unknown> | Sons of Mogh | (DS9) |
| Botha | Botha | Persistence of Vision | (VOY) |
| Breen | <unknown> | Hero Worship | (TNG) |
| Brekkians | Brekka | Symbiosis | (TNG) |
| Bringloidi | Bringloid 5 | Up the Long Ladder | (TNG) |
| Briori | Delta Quad. | The 37's | (VOY) |
| Bynars | Bynaus | 11001001 | (TNG) |
| Camorites | Camor 5 | Bloodlines | (TNG) |
| Capellans | Capella 4 | Friday's Child | (TOS) |
| Cardassians | Cardassia | The Wounded | (TNG) |
| Chalnoth | Chalna | Allegiance | (TNG) |
| Chameloid | <unknown> | The Undiscovered Country | (FLM) |
| Chrysalians | <unknown> | The Price | (TNG) |
| Coalescent Organism | N/A | Aquiel | (TNG) |
| Colyus | Yadera 2 | Shadowplay | (DS9) |
| Companion | Gamma Cana. | Metamorphosis | (TOS) |
| Consciousness Parasite | N/A | Coda | (VOY) |
| Cravic | Delta Quad. | Prorotype | (VOY) |
| Crystalline Entity | <unknown> | Datalore | (TNG) |
| Cytherians | Galaxy Centre | The Nth Degree | (TNG) |
| D'Arsay | <unknown> | Masks | (TNG) |
| Dachlyds | <unknown> | Captains Holiday | (TNG) |
| Dal'Rok | Bajor | The Storyteller | (DS9) |
| Daliwakan | Delta Quad. | The Cloud | (VOY) |
| Debrune | Barradas 3 | Gambit | (TNG) |
| Deltans | Delta 4 | The Motion Picture | (FLM) |
| Denebians | <unknown> | I, Mudd | (TOS) |
| Devidians | Devidia 2 | Times Arrow | (TNG) |
| Dikironium Cloud Creature | Space | Obsession | (TOS) |
| Distortion Ring Being | Space | Twisted | (VOY) |
| Doosodarians | <unknown> | Interface | |
| Dopterians | <unknown> | The Forsaken | (DS9) |
| Dosi | Gamma Quad. | Rules of Acquisition | (DS9) |
| Douwd | <unknown> | The Survivors | (TNG) |
| Drayans | Drayan 2 | Innocence | (VOY) |
| Drella | Alpha Carine. | Wolf in the Fold | (TOS) |
| Dryworm | Antos 4 | Who Mourns for Adonais | (TOS) |
| Edo | Rubicun 3 | Justice | (TNG) |
| Edo God | Rubicun 3 | Justice | (TNG) |
| Ekosians | Ekos | Patterns of Force | (TOS) |
| El-Aurians | Destroyed | Q Who | (TNG) |
| Elasians | Elas | Elaan of Troyius | (TOS) |
| Elaysians | <unknown> | Melora | (DS9) |
| Emergent Life-form | <unknown> | Emergence | (TNG) |
| Enarans | Enara Prime | Remember | (VOY) |
| Ennis/Nol-Ennis | Gamma Quad. | Battle Lines | (DS9) |
| Etanian Order | Delta Quad. | Rise | (VOY) |
| Excalbian | Excalibia | The Savage Curtain | (TOS) |
| Exocomp | N/A | The Quality of Life | (TNG) |
| Eymorg/Morg | Sigma Drac. 6 | Spock's Brain | (TOS) |
| Fabrini | Fabrina | For the World is Hollow... | (TOS) |
| Farn | Delta Quad. | Unity | (VOY) |
| Farpoint Station | Deneb 4 | Encounter at Farpoint | (TNG) |
| Ferengi | Fereginar | The Last Outpost | (TNG) |
| Fire Beast of Sullus | Drayan | Innocence | (VOY) |
| Founders | Delta Quad. | The Search | (DS9) |
| Frunalian | <unknown> | Emissary | (DS9) |
| Galipotans | <unknown> | The Wire | (DS9) |
| Gallamite | <unknown> | The Maquis | (DS9) |
| Gatherers | Acamar 3 | The Vengeance Factor | (TNG) |
| Gomtuu | Space | Tin Man | (TNG) |
| Gorgan | <unknown> | And the Children Shall Lead | (TOS) |
| Gorn | Cestus 3 | Arena | (TOS) |
| Grazerite | <unknown> | Homefront | (DS9) |
| Gree | Delta Quad. | Elogium | (VOY) |
| Grisella | <unknown> | The Ensigns of Command | (TNG) |
| Haakonians | Delta Quad. | Jetrel | (VOY) |
| Halkans | <unknown> | Mirror, Mirror | (TOS) |
| Hill People | <unknown> | A Private Little War | (TOS) |
| Horta | Janus 6 | The Devil in the Dark | (TOS) |
| Humans | Earth | Star Trek | (ALL) |
| Hunters | Gamma Quad. | Captive Persuit | (DS9) |
| Hupyrians | <unknown> | The Nagus | (DS9) |
| Husnock | <unknown> | The Survivors | (TNG) |
| Iconians | Iconia | Contagion | (TNG) |
| Idanians | <unknown> | A Simple Investigation | (DS9) |
| Ilidarians | Ilidaria | Cathexis | (VOY) |
| Inheritors | Earth | Tattoo | (VOY) |
| Interphasic Organisms | <unknown> | Phantasms | (TNG) |
| Iotians | Sigma Iotia 2 | A Piece of the Action | (TOS) |
| Isis | Unknown | Assignment Earth | (TOS) |
| Iyaarans | <unknown> | Liaisons | (TNG) |
| J'Naii | <unknown> | The Outcast | (TNG) |
| Jarada | Torona 4 | The Big Goodbye | (TNG) |
| Jem'Hadar | Gamma Quad. | The Jem'Hadar | (DS9) |
| Junior | Alpha Omicr. | Galaxy's Child | (TNG) |
| Kalandans | <unknown> | That Which Survives | (TOS) |
| Karemma | Gamma Quad. | Rules of Acquisition | (DS9) |
| Kazon | Various | Caretaker | (VOY) |
| Kellerun | <unknown> | Armageddon Game | (DS9) |
| Kelvans | Kelva | By Any Other Name | (TOS) |
| Kerelian | <unknown> | Lessons | (TNG) |
| Kes | Kesprytt 3 | Attached | (TNG) |
| Klingons | Qo'noS | Errand of Mercy | (TOS) |
| Kobliad | <unknown> | The Passenger | (DS9) |
| Kohms | Omega 4 | The Omega Glory | (TOS) |
| Koinonians | <unknown> | The Bonding | (TNG) |
| Kressari | <unknown> | The Circle | (DS9) |
| Ktarians | Kataria 7 | The Game | (TNG) |
| L-S6 Life-form | L-S6 | The Alternate | (DS9) |
| LB10445 | Devidia 2 | Times Arrow | (TNG) |
| Legarans | Legara 4 | Sarek | (TNG) |
| Lenarians | <unknown> | Tapestry | (TNG) |
| Lethean | <unknown> | The Sword of Kahless | (DS9) |
| Leyrons | Malkus 9 | Loud as a Whisper | (TNG) |
| Ligonians | Ligon 2 | Code of Honor | (TNG) |
| Lissepians | Lissepia | The Maquis | (DS9) |
| Lothra | <unknown> | Melora | (DS9) |
| M-113 Creature | M-113 | The Man Trap | (TOS) |
| Makers | Andromeda | I, Mudd | (TOS) |
| Malcorians | Malcor 3 | First Contact | (TNG) |
| Malurians | Malurian Sys. | The Changeling | (TOS) |
| Manchovites | <unknown> | Business as Usual | (DS9) |
| Marijne 7 Beings | Marijne 7 | Interface | (TNG) |
| Mathenites | <unknown> | Second Skin | (DS9) |
| Medusans | <unknown> | Is There in Truth No Beauty? | (TOS) |
| Melkotians | <unknown> | Spectre of the Gun | (TOS) |
| Mellitus | Alpha Majoris | Wolf in the Fold | (TOS) |
| Menthar | <unknown> | Booby Trap | (TNG) |
| Metron | <unknown> | Arena | (TOS) |
| Microbiotic Colony | N/A | A Matter of Honor | (TNG) |
| Microbrain | Velara 3 | Home Soil | (TNG) |
| Microvirus | N/A | The Vengeance Factor | (TNG) |
| Mikhal Travelers | Delta Quad. | Darkling | (VOY) |
| Mikulaks | <unknown> | Hollow Pursuits | (TNG) |
| Minnobia | <unknown> | Business as Usual | (DS9) |
| Mintakans | Mintaka 3 | Who Watches the Watchers? | (TNG) |
| Miradorn | <unknown> | Vortex | (DS9) |
| Mizarians | Mizar 2 | Allegiance | (TNG) |
| Moriarty | Holodeck | Elementary, Dear Data | (TNG) |
| Moropa | <unknown> | Allegiance | (TNG) |
| Nagilum | Space | Where Silence has Lease | (TNG) |
| Nanites | Senegal | Evolution | (TNG) |
| Napeans | <unknown> | Eye of the Beholder | (TNG) |
| Nasari | Delta Quad. | Favorite Son | (VOY) |
| Nausicaans | <unknown> | Samaritan Snare | (TNG) |
| Nechani | Delta Quad. | Sacred Ground | (VOY) |
| Nezu | Delta Quad. | Rise | (VOY) |
| Nitrium Metal Parasites | Space | The Cost of Living | (TNG) |
| Nucleogenic Cloud Being | Space | The Cloud | (VOY) |
| Numiri | Delta Quad. | Ex Post Facto | (VOY) |
| Nyberrite Alliance | <unknown> | The Way of the Warrior | (DS9) |
| Ocampa | Delta Quad. | Caretaker | (VOY) |
| Old Ones | Exo 3 | What Are Little Girls... | (TOS) |
| Old Ones | <unknown> | Catspaw | (TOS) |
| Onaya | <unknown> | The Muse | (DS9) |
| Ophidian | Devidia 2 | Times Arrow | (TNG) |
| Organians | Organia | Errand of Mercy | (TOS) |
| Orions | Orion | The Cage | (TOS) |
| Ornarans | Ornara | Symbiosis | (TNG) |
| Pah-wraiths | Bajor | The Assignment | (DS9) |
| Pakleds | <unknown> | Samaritan Snare | (TNG) |
| Paradas | Parada Sys. | Whispers | (DS9) |
| Parein | Delta Quad. | Unity | (VOY) |
| Paxans | Ngame Neb. | Clues | (TNG) |
| Peljenite | <unknown> | Family Business | (DS9) |
| Petarian | <unknown> | Family Business | (DS9) |
| Photonic Being | Delta Quad. | Heroes and Demons | (VOY) |
| Platonians | Sahndara | Plato's Stepchildren | (TOS) |
| Portal | Tkon Empire | The Last Outpost | (TNG) |
| Preservers | <unknown> | The Paradise Syndrome | (TOS) |
| Promellians | <unknown> | Booby Trap | (TNG) |
| Providers | Triskelion | The Gamesters of Triskelion | (TOS) |
| Proxcinians | <unknown> | Business as Usual | (DS9) |
| Prytt | Kesprytt | Attatched | (TNG) |
| Pygorians | <unknown> | The Maquis | (DS9) |
| Q | Continuum | Encounter at Farpoint | (TNG) |
| Quantum Singularity Entity | space | Timescape | (TNG) |
| Quasi-energy Microbes | space | Realm of Fear | (TNG) |
| Rakhari | Rakhar | Vortex | (DS9) |
| Redjack | <unknown> | Wolf in the Fold | (TOS) |
| Reegrunion | <unknown> | Sanctuary | (DS9) |
| Reptohumanoid Hatchling | Delta Quad. | Parturition | (VOY) |
| Rigelians | Rigel | Journey to Babel | (TOS) |
| Romulans | Romulus | Balance of Terror | (TOS) |
| Rutians | Rutia 4 | The High Ground | (TNG) |
| Sakari | Delta Quad. | Blood Fever | (VOY) |
| Saltah'na | Gamma Quad. | Dramatis Personae | (DS9) |
| Sand Bats | Manark 4 | The Empath | (TOS) |
| Satarrans | Sothis 3 | Conundrum | (TNG) |
| Scalosians | Scalos | Wink of an Eye | (TOS) |
| Scathos | Delta Quad. | Elogium | (VOY) |
| Selay | Beta Renna | Lonely Among Us | (TNG) |
| Sheliak | Shelia | The Ensigns of Command | (TNG) |
| Skrreea | Draylon 2 | Sanctuary | (DS9) |
| Solanagen-based Entities | Subspace | Schisms | (TNG) |
| Spot | Earth | Data's Day | (TNG) |
| Swarm | Delta Quad. | The Swarm | (VOY) |
| Symbiont | Trill | Equilibrium | (DS9) |
| T'Lani | T`Lani | Armageddon Game | (DS9) |
| T-Rogorans | <unknown> | Sanctuary | (DS9) |
| Tagrans | Tagra 4 | True Q | (TNG) |
| Tak Tak | Delta Quad | Macrocosm | (VOY) |
| Takarans | <unknown> | Suspicions | (TNG) |
| Takarians | Delta Quad. | False Profits | (VOY) |
| Talarians | <unknown> | Heart of Glory | (TNG) |
| Talavians | <unknown> | Things Past | (DS9) |
| Talosians | Talos 4 | The Cage | (TOS) |
| Tamarians | <unknown> | Darmok | (TNG) |
| Tanugans | Tanuga 4 | A Matter of Perspective | (TNG) |
| Tarellians | Tarella | Haven | (TNG) |
| Taresians | Delta Quad. | Favorite Son | (VOY) |
| Tarkannans | Delta Quad. | Innocence | (VOY) |
| Tavnians | <unknown> | The Muse | (DS9) |
| Tellarites | <unknown> | Journey to Babel | (TOS) |
| Terellians | <unknown> | Liaisons | (TNG) |
| Terrellians | <unknown> | Life Support | (DS9) |
| Thasians | Thasus | Charlie X | (TOS) |
| Tholians | <unknown> | The Tholian Web | (TOS) |
| Tosk | Gamma Quad. | Captive Pursuit | (DS9) |
| Traveler | Tau Alpha C | Where No One has Gone... | (TNG) |
| Trelane | <unknown> | The Squire of Gothos | (TOS) |
| Trianic Energy Beings | Nebula | Cathexis | (VOY) |
| Tribble | <unknown> | The Trouble with Tribbles | (TOS) |
| Trill | Trill | The Host | (TNG) |
| Troglytes | Ardana | The Cloud Minders | (TOS) |
| Troi, Ian Andrew | <unknown> | The Child | (TNG) |
| Troyians | Troyius | Elaan of Troyius | (TOS) |
| Two-dimensional Creatures | space | The Loss | (TNG) |
| Two-Headed Malgorian | <unknown> | Progress | (DS9) |
| Tzenkethi | Tzenkethi | The Adversary | (DS9) |
| Ugly Bags of Mostly Water | Earth | Home Soil | (TNG) |
| Ullians | <unknown> | Violations | (TNG) |
| V'Ger | Earth | The Motion Picture | (FLM) |
| Valerians | <unknown> | Dramatis Personae | (DS9) |
| Valtese | Valt Minor | The Perfect Mate | (TNG) |
| Vek | <unknown> | Business as Usual | (DS9) |
| Verillians | <unknown> | None | |
| Vians | Manaran Sys. | The Empath | (TOS) |
| Vidiians | Delta Quad. | Phage | (VOY) |
| Vok'sha | Rakella Prime | Heroes and Demons | (VOY) |
| Vorgons | The Future | Captain's Holiday | (TNG) |
| Vorta | Gamma Quad. | The Search | (VOY) |
| Vulcans | Vulcan | Amok Time | (TOS) |
| Wadi | Gamma Quad. | Move Along Home | (DS9) |
| Wise Ones | <unknown> | The Paradise Syndrome | (TOS) |
| Wogneer Creatures | Ordek Nebula | Allegiance | (TNG) |
| Xepolites | <unknown> | The Maquis | (DS9) |
| Yaderans | Yadera 2 | Shadowplay | (DS9) |
| Yallitians | Delta Quad. | Phage | (VOY) |
| Yalosians | <unknown> | Improbable Cause | (DS9) |
| Yangs | Omega 4 | The Omega Glory | (TOS) |
| Yattho | Beta Quad. | Before and After | (VOY) |
| Yridians | <unknown> | Birthright | (TNG) |
| Zakdorn | <unknown> | Peak Performance | (TNG) |
| Zaldans | <unknown> | Coming of Age | (TNG) |
| Zalkonians | Zalcon | Transfigurations | (TNG) |
| Zetarians | Zetar | The Lights of Zetar | (TOS) |
| Zibalians | <unknown> | The Most Toys | (TNG) |
